In recent years, Semaglutide has gained significant attention as an effective treatment option for weight loss. This medication belongs to the group of drugs called GLP-1 receptor agonists (glucagon-like peptide-1 receptor agonists) that have demonstrated considerable effectiveness in supporting weight loss efforts.
The FDA-approved formulations of Semaglutide, Ozempic and Wegovy, have become household names. However, many people are now turning to compounded Semaglutide as an alternative due to accessibility issues, side effects, or the need for customized doses.
This article explores what is compounded Semaglutide, how it differs from commercially available options, its benefits, and essential considerations.
Key takeaways:
Compounded Semaglutide is an alternative to commercially available Semaglutide (Ozempic, Wegovy) that allows for personalized dosing.
Compounded Semaglutide is offered by licensed compounding pharmacies and requires a valid prescription by a healthcare practitioner.
Suitable candidates for compounded Semaglutide include those who need personalized dosing, have cost concerns, or seek an alternative due to side effects.
Some potential benefits of compounded Semaglutide include individualized dosing and a more cost-effective solution to weight management.
Considerations for compounded Semaglutide include the importance of sourcing from reputable providers due to safety and efficacy concerns.
What is Compounded Semaglutide?
Compounded Semaglutide is a customized form of the weight loss medication Semaglutide prepared by compounding pharmacies.
Semaglutide is a GLP-1 (glucagon-like peptide-1) receptor agonist. It has also been shown to be effective in supporting weight loss by reducing appetite and promoting a feeling of fullness. [1]
Unlike the Semaglutide brand-name medications, like Ozempic or Wegovy, compounded Semaglutide is tailored in dosage or form, such as being available in oral or injectable versions.
Also, compounded Semaglutide is often less expensive than brand-name weight loss medications like Ozempic or Wegovy. This is one of the reasons why compounded Semaglutide has gained popularity as a cost-effective weight loss alternative to Ozempic or Wegovy.
Why is Semaglutide Being Compounded?
The primary reason why Semaglutide is being compounded is to address the shortages of FDA-approved brands, including Ozempic. [2]
Clinical research suggests that the shortage of medication can result in interruptions in patient treatments, negatively impacting the outcomes. Compounded or custom Semaglutide addresses these issues, allowing patients to continue their treatment regularly. [3] [4]
The compounding of Semaglutide during shortages is permitted by the FDA when specific conditions are met, including:
- Using the same Semaglutide salts as in FDA-approved medications.
- Compounding the pharmaceutical ingredients for the medication in compliance with state and federal regulations.
- Sourcing the Semaglutide salt forms from FDA-registered facilities.
- Dispensing compounded Semaglutide only with a prescription from a licensed healthcare professional.
Another reason Semaglutide is being compounded is to ensure wider availability of this weight loss medication at a lower cost. The cost of compounding Semaglutide is much lower than that of Ozempic, Wegovy, and other weight loss medications such as Zepbound and Mounjaro. [5]
This makes the compounded versions of Semaglutide cheaper than Ozempic and other weight loss drugs.
If you are looking for Semaglutide alternatives, you can make a telehealth appointment with Amp Health’s weight loss providers. Our doctor will analyze your case and prescribe the most suitable strength and form of compounded Semaglutide. This will help you achieve your weight loss goals without treatment interruptions and heavy expenditure.
How Does Compounded Semaglutide Work?
Compounded or custom Semaglutide works as a GLP-1 agonist. This means it mimics the body’s GLP-1 hormone, which helps to slow gastric emptying, regulate blood sugar levels, control insulin secretion, and reduce appetite. [6]
By slowing gastric emptying and enhancing insulin secretion, Semaglutide can contribute to weight loss.
Additionally, by acting on brain centers related to hunger, Semaglutide reduces cravings and helps manage portion control. [7]
Compounded Semaglutide follows the same mechanism of action as commercially available Semaglutide drugs. However, the dose and form can be adapted to meet a patient’s specific needs, allowing them to see the expected weight loss results without the risk of severe side effects.
Furthermore, compounded weight loss injections and oral drops and tablets offer more flexibility in administration, as some patients may be able to choose a medication that differs in dosage form from those available through branded options.
Benefits of Compounded Semaglutide
Personalized Dosing
One of the primary advantages of custom Semaglutide is the ability to adjust the dose precisely to an individual’s needs. This is beneficial for patients who may be sensitive to higher doses or for those who are titrating their medication to manage side effects effectively.
Cost-Effective Alternative
Brand-name versions of Semaglutide, like Ozempic and Wegovy, are expensive. Compounded Semaglutide, on the other hand, is often more affordable as it is made by compounding pharmacies.
This lower price point makes compounded weight loss injections more accessible for people seeking weight loss treatment on a budget.
So, compounded Semaglutide can provide a more budget-friendly option compared to brand-name drugs. For people without insurance coverage for branded GLP-1 medications or who face high out-of-pocket costs, compounded Semaglutide may offer a viable alternative.
Availability in Various Forms
Brand-name Semaglutide drugs are available in specific forms. For example, Wegovy and Ozempic are available as injectables only, while Rybelsus is available as oral tablets. [8]
Compounded versions, on the other hand, can offer alternative delivery methods, including injectables as well as oral formulations. This can offer a choice to patients who may prefer oral Semaglutide for convenience or find it easier to use injectables due to their weekly dosing schedule.
Potential to Address Side Effects
Some patients experience severe side effects to standard doses of Semaglutide that are difficult to tolerate. A compounded version with a customized, lower dose can help manage or mitigate these issues.
Patient Compliance and Flexibility
Patients who find the titration schedules of brand-name products difficult to follow may benefit from compounded weight loss injections or oral tablets and drops, allowing a slower increase in dosage or a more manageable frequency of administration.
This is expected to provide flexibility and improve patient compliance with the weight loss treatment.
Where and How is Compounded Semaglutide Available?
Compounded Semaglutide is typically available through licensed compounding pharmacies, which can only provide compounded medications when prescribed by a licensed healthcare provider.
Patients interested in compounded Semaglutide should seek a reputable compounding pharmacy with experience in producing Semaglutide formulations. It’s essential to ensure that the pharmacy operates under proper licensing and quality standards to ensure product safety and efficacy.
Importance of Choosing Reputable Providers for Safety and Efficacy
The quality of compounded medications can vary between pharmacies, making it crucial to choose a reputable provider.
While compounded Semaglutide offers flexibility, it does not undergo the same rigorous FDA approval process as commercially available medications, which means that the quality, potency, and efficacy of the compounded product may vary.
Hence, patients are encouraged to get a valid prescription of compounded Semaglutide from a reputable, licensed pharmacy and work closely with their healthcare providers to monitor the effectiveness of the treatment and adjust it as necessary.
Potential Risks and Side Effects to Consider
While compounded Semaglutide may offer several benefits, potential risks and side effects still exist, similar to those associated with FDA-approved forms.
Some common side effects may include nausea, abdominal pain, vomiting, diarrhea, and fatigue. Since compounded formulations can vary, there may be additional risks related to the purity, sterility, and stability of the product.
Patients should discuss any side effects with their healthcare provider, who can help manage and adjust dosing as needed.
Who Should Consider Compounded Semaglutide?
Compounded Semaglutide may be a suitable option for specific individuals who have unique needs or circumstances that make standard brand-name medications less ideal.
Here are some groups of people who might consider compounded Semaglutide:
- Need Customized Dosages: Patients who cannot tolerate the standard dosage increments in commercial products may benefit from the personalized dosing offered by compounded semaglutide.
- Are Seeking Cost-Effective Alternatives: Patients with limited insurance coverage or facing high costs for branded medications might find compounded versions more affordable.
- Have Sensitivity to Standard Doses: Those who experience adverse effects on FDA-approved doses may benefit from lower-dose, compounded formulations.
- Facing Drug Shortages: People may also opt for compounded Semaglutide if they face access or availability issues with the branded products, especially during times of high demand.
- Weight Loss Guidance: Some patients prefer the ability to work closely with their health care providers to fine-tune their dosage, which can be especially beneficial for those who have struggled to find a tolerable and effective dose. In these cases, getting the medication from a reputable source that also offers coaching, and nutrition guidance is often preferred by patients to improve results and ensure the safety of the weight loss treatment.
How Much Does Compounded Semaglutide Cost?
When considering compounded Semaglutide, the cost structure is an important factor to understand. Injectable compounded Semaglutide prescribed under the Amp Health Program costs around $199 to $299 per month, while oral forms of compounded Semaglutide cost around $349 to $515 per month, based on your plan and dosage.
The exact pricing of compounded Semaglutide at Amp Health primarily depends on the dosage required and the duration of the treatment plan you choose.
Here is a brief breakdown of the cost of oral Semaglutide at Amp Health:
- Initial Cost: For the first month, you will start with a dosage of 1 milligram, which is priced at $299. This initial cost covers the starting dosage necessary to begin your weight loss journey with oral Semaglutide.
- Increasing Dosage: As your treatment progresses, the dosage typically increases to achieve optimal results. In the second and third months, the cost rises to $399 per month to reflect the higher dosage required. This adjustment ensures that you are receiving the appropriate amount of medication to continue your weight loss effectively.
- Flexible Payment Plans: To provide greater affordability and flexibility, AmpHealth offers both 3-month and 12-month plans. These plans are designed to accommodate different financial needs and treatment goals. Opting for these plans can help you manage the cost by providing a more consistent pricing structure over a shorter period.
- For those committed to a long-term weight loss journey, the 12-month plan offers significant savings. By choosing this option, the cost of your medication can be reduced to as low as $199 per month. This plan not only makes the medication more affordable but also simplifies budgeting for your weight loss treatment.
By selecting a plan that fits your needs, you can make the most of the benefits offered by oral Semaglutide while managing costs effectively. Amp Health’s pricing options are designed to support both immediate and long-term weight loss goals, making it a practical choice for those seeking a comprehensive and flexible approach to weight management.
How to Keep the Weight Off After Your stop taking Semaglutide
Stopping Semaglutide can present a challenge for weight maintenance. Research shows that many people who stop taking semaglutide experience notable weight regain, often leading them back to the medication.
A recent study in the Journal of Pharmacology and Therapeutics found that a majority of individuals regained most of the lost weight within a year of discontinuing semaglutide. This pattern, often called “Ozempic rebound,” highlights the role of long-term lifestyle adjustments in sustaining weight loss after treatment.
Consider Sara, a 55-year-old woman who had lost 30 pounds on semaglutide. Feeling confident, she stopped the medication, only to gradually regain weight as old habits returned. Seeing the scale climb again, she chose to restart semaglutide, realizing that a comprehensive, balanced approach – medication, diet, and regular activity – was essential to her long-term success.
With regular nutrition coaching and the appropriate strategies, you can keep the weight off effectively.
Here are 5 key strategies to keep the weight off after you stop taking Semaglutide:
- Start by prioritizing a balanced, sustainable diet that emphasizes whole foods like vegetables, lean proteins, healthy fats, and whole grains. These nutrient-dense choices help manage hunger and maintain steady energy levels, which are key when transitioning off Semaglutide.
- Incorporate regular physical activity into your routine, focusing on a mix of cardio, strength training, and flexibility exercises. Strength training is particularly beneficial as it supports muscle mass, which boosts your metabolism, helping prevent weight regain.
- Mindful eating is another crucial tool. Practicing mindfulness around food choices, portion sizes, and hunger cues can support long-term weight maintenance and reduce mindless snacking.
- Consider setting a consistent meal schedule to regulate your metabolism and prevent overeating. Hydration, quality sleep, and stress management are also essential factors, as they play a big role in appetite regulation and energy levels.
- Keep up with follow-up care, including any recommended check-ins with your weight loss coach at Amp Health. Your healthcare provider can provide accountability, additional strategies, and encouragement to help you stay on track with your weight maintenance goals.
Compounded Semaglutide: Testimonials
“I had struggled with my weight for years, trying various diets and medications with little success. After starting compounded Semaglutide at Amp Health, I noticed a significant reduction in my appetite and cravings. The team at Amp Health guided me through the process, and I felt supported every step of the way.”
-34/F
“As a busy professional, I found it challenging to maintain a healthy weight. When my doctor suggested compounded Semaglutide. I was hesitant at first, but the staff at Amp Health made the experience seamless. I’ve lost over 20 pounds in four months! More importantly, I feel more in control of my eating habits and my overall health.”
-45/M
“I struggled to lose weight for over 15 years. After researching options, I decided to try compounded Semaglutide at Amp Health. The results have been incredible. I’m down 10 pounds in just six weeks. The personalized care I received from the Amp Health team made all the difference. They really listened to my concerns and helped me feel confident in my weight loss journey.”
-48/M
What is Compounded Semaglutide: FAQs
What Is The Difference Between Compounded Semaglutide And Semaglutide?
The primary difference between compounded Semaglutide and standard Semaglutide (such as Ozempic or Wegovy) lies in their formulation and availability.
Standard Semaglutide is a commercially produced medication that has undergone testing and FDA approval for specific indications including chronic weight management. Compounded Semaglutide, on the other hand, is prepared by state-licensed pharmacies, who customize the medication to meet individual patient needs, allowing for personalized dosing, which can be beneficial for those who require lower or adjusted doses.
What Is The Problem With Compounded Semaglutide?
Compounded medications are not FDA-approved and can vary in quality and concentration, depending on the compounding pharmacy’s practices.
This makes it important to get your weight loss medication from a reputable and licensed pharmacy to ensure the safety and efficacy of your treatment.
Can You Lose Weight On Compounded Semaglutide?
Yes, many patients experience weight loss while using compounded Semaglutide, as it functions similarly to branded Semaglutide by regulating appetite and promoting satiety.
By mimicking the GLP-1 hormone, compounded Semaglutide can lead to reduced calorie intake and improved metabolic function.
Why Do People Choose Compounded Semaglutide Over Brand Names?
People may opt for compounded Semaglutide because it is available in different forms and allows for customized dosing, which can help with managing side effects. It can also be more cost-effective and may be available when branded options are difficult to access.
Is Compounded Semaglutide FDA-Approved?
Compounded Semaglutide itself is not FDA-approved. However, compounding pharmacies must operate under state and federal regulations and follow strict guidelines to ensure product quality and patient safety.
Conclusion
Compounded Semaglutide represents a valuable alternative for individuals seeking tailored solutions for managing weight gain or obesity. With its potential for personalized dosing, cost-effective access, and flexible formulation, it provides a unique approach for patients who may not achieve optimal results with FDA-approved drugs like Ozempic or Wegovy.
However, it’s essential to prioritize quality and safety by working with reputable compounding pharmacies and maintaining close communication with healthcare providers.
If you want to know more about what is compounded Semaglutide, you can talk to Amp Health’s healthcare experts. Our healthcare professionals will analyze your medical history and weight loss goals. They will also provide a valid prescription for a suitable dose of compounded Semaglutide to help you lose weight safely and effectively.
You can subscribe to our Amp Health Program, which includes consultations with our doctor, nutritionist, and coach, in addition to the monthly subscription of compounded Semaglutide ($79/month + cost of medication).
If you have any medical questions or concerns, please talk to your healthcare provider. The articles on our website are based on information drawn from medical research, societies and governmental agencies. However, they are not a substitute for professional medical advice, diagnosis, or treatment.
DISCLAIMER
If you have any medical questions or concerns, please talk to your healthcare provider. The articles on our website are based on information drawn from medical research, societies and governmental agencies. However, they are not a substitute for professional medical advice, diagnosis, or treatment.
References:
- https://pubmed.ncbi.nlm.nih.gov/34942372/
- https://pubmed.ncbi.nlm.nih.gov/38685990/
- https://www.ncbi.nlm.nih.gov/books/NBK608470
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6499468/
- https://www.ncbi.nlm.nih.gov/books/NBK585056/
- https://pubmed.ncbi.nlm.nih.gov/33567185/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573908/
- https://www.ncbi.nlm.nih.gov/books/NBK603723/
