Semaglutide and Tirzepatide are two popular medications that have garnered attention for their effectiveness in promoting weight loss. These medications belong to the class of GLP-1 receptor agonists, though they have distinct properties and mechanisms of action that set them apart.
Understanding the comparison of Tirzepatide and Semaglutide is crucial for making informed decisions about weight loss treatment options.
In this blog, we’ll delve into the comparative efficacy, safety profiles, and benefits of Semaglutide vs. Tirzepatide to help you better grasp which might be the right choice for your health goals.
Key Takeaways
- Tirzepatide represents a new class of weight loss drugs known as dual GLP-1 and GIP (gastric inhibitory peptide) receptor agonists.
- Semaglutide is a GLP-1 receptor agonist. It helps support weight loss by reducing hunger and increasing feelings of fullness.
- Tirzepatide has a slightly greater magnitude of weight loss compared to Semaglutide. [8]
- Semaglutide has a well-documented long-term safety profile, with extensive clinical trials and real-world data supporting its use. Tirzepatide’s long-term safety profile is still being established.
- The choice between these medications should be guided by your weight loss goals, treatment preferences, and discussions with your healthcare provider. Refer to our comparison table below.
What is Semaglutide?
Semaglutide is a GLP-1 (glucagon-like peptide-1) receptor agonist. It mimics the action of a naturally occurring hormone that helps regulate appetite. It helps support weight loss by activating GLP-1 receptors in the brain, thus reducing hunger and increasing feelings of fullness.
This effect leads to reduced calorie intake and, consequently, weight loss.
Clinical trials have demonstrated the effectiveness of Semaglutide for weight management. The study showed an average weight reduction of approximately 15% of body weight over 68 weeks. [1] [2]
What Are the Available Forms of Semaglutide For Weight Loss
Semaglutide for weight loss is available in several forms, each offering different options depending on patient preferences and medical needs.
Here’s a breakdown of the available forms of Semaglutide:
Ozempic
Ozempic is an injectable form of Semaglutide. It is administered once a week and is well-regarded for Semaglutide weight loss results.
Wegovy
Wegovy is an FDA-approved injectable form of Semaglutide, specifically indicated for weight management. It is administered once a week and used for chronic weight management in people struggling with obesity.
Rybelsus
Rybelsus is an oral form of Semaglutide. It is taken as a daily tablet and provides a convenient alternative for those who prefer not to use injectable medications.
Compounded Semaglutide Tablets and Drops
Some compounding pharmacies offer Semaglutide in customized injections or oral forms, such as tablets and drops.
The oral forms of compounded Semaglutide for weight loss, such as drops and tablets, are particularly suitable for patients who need specific dosing or have difficulties with injectable forms of branded medications. The injectable forms allow for better flexibility in dosage increments compared to standard FDA-approved injectables.
What Is Tirzepatide?
Tirzepatide for weight loss represents a new class of drugs known as dual GLP-1 and GIP (gastric inhibitory peptide) receptor agonists. It combines the effects of GLP-1 and GIP receptor agonists.
Both GLP-1 and GIP are hormones that play roles in regulating appetite and supporting weight loss.
So, Tirzepatide, like other GLP-1 receptor agonists, such as Semaglutide, slows gastric emptying and reduces appetite. These effects contribute to faster weight loss. In addition, it also acts as a GIP receptor agonist, further regulating both fat metabolism and appetite.
Tirzepatide’s action on GIP receptors adds an additional layer of metabolic regulation, potentially supporting weight reduction. [3] [4]
Clinical studies indicate that Tirzepatide can lead to substantial weight loss, making it a valuable option for patients struggling with obesity and related conditions, such as diabetes and heart disease.
What Are the Available Forms of Tirzepatide For Weight Loss?
As of now, Tirzepatide for weight loss is available only in injectable form.
It is administered as a subcutaneous injection. It is designed for weekly use, typically injected into the abdomen, thigh, or upper arm. This weekly dosing schedule provides a convenient option for patients who prefer less frequent administration compared to daily injections.
Mounjaro and Zepbound are popular brands of Tirzepatide for weight loss.
The standard starting dosage of Mounjaro is 2.5 mg once weekly for 4 weeks. After 4 weeks, the dose can be increased to 5 mg once weekly. Based on weight loss goals and tolerance, the doctor may further increase the dose in increments of 2.5 mg up to the maximum dose of 15 mg once weekly. Zepbound follows a similar dosing schedule.
It is important to note that Tirzepatide has not yet been approved in other forms, such as oral tablets or drops. However, ongoing research and development may explore alternative delivery methods in the future to enhance patient convenience and adherence.
Mechanism Of Action for Weight Loss: GLP-1 Vs. GLP-1 & GIP
The mechanisms by which GLP-1 and a combination of GLP-1 and GIP contribute to weight loss differ in their pathways and effects on the body.
Here’s a detailed look at how each mechanism works:
GLP-1 Mechanism of Action
GLP-1 is a hormone that plays a significant role in regulating appetite and controlling gastric emptying. GLP-1 agonists act on the brain’s appetite control centers to reduce hunger and increase feelings of fullness.
In addition, by slowing down the rate at which food leaves the stomach, GLP-1 agonists prolong satiety and reduce calorie consumption. This helps decrease overall food intake, leading to weight loss. [5]
GLP-1 & GIP Dual Mechanism of Action
Tirzepatide, a newer medication, combines GLP-1 and GIP receptor agonism, offering a more comprehensive approach to weight management:
GIP’s role in enhancing metabolic processes and influencing fat metabolism, alongside GLP-1’s appetite regulation, can result in more effective weight loss and metabolic improvements. [5] [6]
So, which is better, Tirzepatide or Semaglutide?
Research indicates that Tirzepatide’s dual action offers promising results in appetite control and weight management, potentially outperforming GLP-1-only medications. [6]
Efficacy Of Semaglutide Vs. Tirzepatide In Weight Loss
In clinical trials, Semaglutide has shown to produce substantial weight loss. The STEP program demonstrated that participants could lose an average of 15% of their body weight with Semaglutide over 68 weeks. [2]
Tirzepatide has shown even greater weight loss potential than Semaglutide.
In the SURMOUNT-1 trial, participants treated with Tirzepatide achieved an average weight loss of approximately 22.5% of their body weight over 72 weeks, which is higher than the weight loss seen with Semaglutide. [7] [8]
This suggests that Tirzepatide weight loss results might have a slightly greater magnitude compared to Semaglutide.
The higher effectiveness of Tirzepatide could be attributed to its dual-action mechanism. However, Semaglutide has a longer track record and established efficacy in weight management, making it a well-documented option.
So, the choice between Tirzepatide vs. Semaglutide for weight loss should be guided by your health goals and treatment preferences following discussions with your healthcare provider.
Comparison Of Semaglutide and Tirzepatide Side Effects
Both Semaglutide and Tirzepatide cause a few side effects and share a similar safety profile.
Here are some side effects of these weight loss drugs you should be aware of.
Semaglutide Side Effects
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Reduced Appetite
- Headache
- Injection Site Reactions
- Gallbladder Issues, such as gallstones
- Pancreatitis
- Thyroid issues, including thyroid tumors
Tirzepatide Side Effects
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Abdominal pain
- Reduced appetite
- Dizziness
- Injection site reactions
- Gastroesophageal reflux disease (GERD)
- Possible thyroid issues
- Risk of pancreatitis
- Potential gallbladder problems
Among these two drugs, Semaglutide has a well-documented long-term safety profile, with extensive clinical trials and real-world data supporting its use.
However, Tirzepatide’s long-term safety profile is still being established. Initial studies and clinical trials show a safety profile comparable to other GLP-1 agonists, but long-term data is needed to confirm its overall safety.
Semaglutide and Tirzepatide: Cost Comparison
Both Semaglutide (Wegovy and Ozempic) and Tirzepatide (Mounjaro) have similar price ranges, generally falling between $900 to $1,800 per month depending on the product and dosage.
The injectable branded versions of Semaglutide, such as Ozempic and Wegovy, cost about $900 to $1,500 per month. The cost of Mounjaro typically ranges between $1,000 to $1,800 per month.
Compounded versions of these drugs are generally more affordable than branded medications. Injectable compounded Semaglutide prescribed under the AmpHealth Program costs around $199 to $299 per month, while oral forms of compounded Semaglutide cost around $349 to $515 per month, based on your plan and dosage.
Comparison of Tirzepatide vs Semaglutide
| Feature | Semaglutide | Tirzepatide |
|---|---|---|
| Best For | Semaglutide) is prescribed for adults with obesity (BMI ≥30) or those who are overweight (BMI ≥27) | Tirzepatide is prescribed when the patient’s weight loss target is more aggressive (higher weight loss) |
| Mechanism of Action | Single: GLP-1 Receptor Agonist | Dual: GLP-1 & GIP Receptor Agonist |
| Efficacy for Weight Loss | Effective for weight loss, but lower compared to Tirzepatide | More effective for weight loss compared to Semaglutide |
| Metabolic Goals | Reductions in blood glucose levels and insulin resistance with Semaglutide are lower than those with Tirzepatide. | Tirzepatide has shown more significant reductions in blood glucose levels and insulin resistance than Semaglutide. |
| Dosage Form | Injectable, Oral | Injectable |
| Frequency | Weekly (injectable), Daily (oral) | Weekly |
| Side Effects | Nausea, Vomiting, Diarrhea, Constipation, Fatigue | Nausea, Vomiting, Diarrhea, Constipation, Fatigue |
| Cost | Without insurance coverage, the cost of Semaglutide is as follows: Branded drugs (e.g., Wegovy, Ozempic): $900 to $1,500 per month AmpHealth Program (based on plan and dosage): $199 to $299 per month | Without insurance coverage, the cost of Tirzepatide is as follows: Branded drug (e.g., Mounjaro): $1,000 to $1,800 per month AmpHealth Program (based on plan and dosage): $349 to $515 per month |
Who Should Consider Semaglutide?
If you are seeking a well-established medication with a long safety record and effective results for weight loss, consider semaglutide.
If you want to know more about compounded Semaglutide and whether it could be a good option for you, you can get in touch with our healthcare experts at Amp Health. Our doctors will evaluate your medical history and discuss your preferences, including expected weight loss, to prescribe a suitable dosage. Our doctors will also recommend a personalized nutrition plan to help you keep the weight off and improve your overall health.
Who Should Consider Tirzepatide?
If you are seeking potentially greater weight loss or prefer an aggressive approach to weight management and have not found success with other medications, Tirzepatide may be worth considering.
Semaglutide and Tirzepatide Alternatives: Types, Frequency, Costs
| Alternatives | Type | Frequency | Cost | Other Information |
|---|---|---|---|---|
| Compounded Semaglutide | Injectable/Oral | Varies (customizable) | Moderate | Customizable dosages; may be more accessible and potentially cheaper than brand-name drugs like Wegovy. |
| Oral Semaglutide | Oral | Daily | Moderate to High | Convenient for those who prefer not to use injectables, has a similar mechanism to Wegovy. |
| Surgical Interventions | Surgical | Single procedure | Very High | Includes options like gastric bypass and sleeve gastrectomy, requires significant long-term commitment, and involves higher risks. |
| Diet Adjustment | Non-pharmaceutical | Daily | Varies | Cost depends on a chosen diet and requires a consistent commitment to see results. |
| Exercise and Physical Activity | Non-pharmaceutical | Daily/Weekly | Low to Moderate | Costs vary based on whether gym membership or personal trainers are used; significant health benefits. |
| Behavioral Therapy | Non-pharmaceutical | Weekly to Monthly | Moderate to High | Costs vary by therapist and frequency and can address underlying behavioral issues related to eating. |
| Mindfulness and Stress Management | Non-pharmaceutical | Daily/As needed | Low to Moderate | Includes practices like yoga and meditation, is cost-effective, and can be done at home. |
This table summarizes the different alternatives to Semaglutide and Tirzepatide to help you make informed decisions.
Among these, compounded medications are commonly preferred as cost-effective alternatives. Compounded options offer flexibility in dosing, cost savings, and alternative delivery methods.
Long-Term Considerations: Sustainability And Lifestyle
Weight Maintenance with Semaglutide and Tirzepatide
Semaglutide has demonstrated significant weight loss in clinical trials and real-world studies.
However, maintaining weight loss requires continued adherence to medication and lifestyle changes. Also, people using these drugs who continue with the medication are more likely to sustain weight loss compared to those who stop treatment.
Importance of Diet and Exercise Alongside Medication
Medications alone cannot substitute for healthy eating habits and sustainable weight loss.
Semaglutide and Tirzepatide are most effective when combined with a balanced diet and healthy lifestyle. Hence, adhering to a regular exercise plan and a diet rich in whole foods, lean proteins, vegetables, and whole grains is necessary to support weight loss and maintain results.
What Happens When Treatment Stops
Upon discontinuation of Semaglutide or Tirzepatide, the body might revert to pre-treatment weight levels if lifestyle changes are not maintained. However, transitioning off the medication gradually while implementing robust lifestyle strategies can help mitigate weight regain.
Risk of Regaining Weight
Maintaining weight loss after stopping medication requires a strong commitment to healthy eating and regular physical activity. Behavioral factors such as emotional eating or lack of exercise can also contribute to weight regain.
Continued support from your healthcare providers, including nutritional counseling and fitness guidance, can help manage weight effectively even after discontinuing medication.
Testimonials
“Semaglutide transformed my weight loss journey at Amp Health with consistent results, and the support has been exceptional throughout.”
– 24/Male“Tirzepatide from Amp Health exceeded my expectations, delivering impressive weight loss with comprehensive support and personalized care.”
– 29/Female“With Amp Health’s guidance, Semaglutide has been very effective for my weight management – highly effective and well-supported treatment.”
– 41/Male
Conclusion
Both Semaglutide and Tirzepatide offer valuable weight loss benefits but cater to different needs and preferences.
Semaglutide, with its proven track record in both appetite control and weight loss, remains a strong option for many patients. Its established efficacy and safety profile make it a reliable choice for achieving significant weight reduction.
On the other hand, Tirzepatide’s dual-action mechanism provides a promising new approach. While Tirzepatide shows exciting potential, more long-term data will be needed to fully establish its benefits and safety profile.
Ultimately, the choice between Semaglutide vs. Tirzepatide should be guided by your health goals, treatment preferences, and discussions with your healthcare provider.
You can talk to our healthcare experts to learn more about which is better, Tirzepatide or Semaglutide. You can also subscribe to our Amp Health Program, which includes consultations with our doctor, nutritionist, and coach, in addition to the monthly subscription of compounded Semaglutide ($79/month + cost of medication).
DISCLAIMER
If you have any medical questions or concerns, please talk to your healthcare provider. The articles on our website are based on information drawn from medical research, societies and governmental agencies. However, they are not a substitute for professional medical advice, diagnosis, or treatment.
References:
- https://pubmed.ncbi.nlm.nih.gov/34942372/
- https://pubmed.ncbi.nlm.nih.gov/33567185/
- https://pubmed.ncbi.nlm.nih.gov/35658024/
- https://pubmed.ncbi.nlm.nih.gov/36251836/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992880/
- https://www.ncbi.nlm.nih.gov/books/NBK551568/
- https://www.nejm.org/doi/full/10.1056/NEJMoa2206038
- https://www.acc.org/Latest-in-Cardiology/Journal-Scans/2024/07/15/14/37/semaglutide-vs-tirzepatide
