People seeking effective weight loss solutions and a healthier lifestyle are increasingly turning to Semaglutide and Mounjaro. These medicines are designed to support obesity management through various physiological mechanisms.
However, Semaglutide and Mounjaro have differences in their composition, benefits, mechanism of action, and side effects.
This blog aims to provide Semaglutide vs. Mounjaro comparison, exploring their mechanisms, effectiveness, side effects, and suitability for different individuals.
Key takeaways:
Semaglutide and Mounjaro are both weight loss medications, each having distinct mechanisms and benefits.
- Semaglutide is a GLP-1 receptor agonist, while Mounjaro combines GLP-1 and GIP receptor agonist effects for enhanced appetite control and insulin sensitivity.
- While both Semaglutide and Mounjaro are effective for weight loss, the dual mechanism of Mounjaro may offer enhanced results.
- Compounded versions of Semaglutide and Mounjaro offer cheaper alternatives to branded drugs, making them cost-effective substitutes for weight loss.
- Consultation with healthcare providers is essential to determine which medication is best suited based on personal health needs and preferences.
What is Semaglutide?
Semaglutide is a weight loss medication that acts as a GLP-1 receptor agonist. GLP-1 (glucagon-like peptide-1) is a hormone that plays a role in regulating appetite, carbohydrate metabolism, and insulin secretion. [1]
Clinical research has established that Semaglutide can help with weight loss, when used in combination with a healthy diet and regular exercise. In some studies, participants experienced average weight reductions of 15% or more of their total body weight. [2]
GLP-1 medications for weight loss containing Semaglutide are available as an injection under the brand names Ozempic and Wegovy and as oral tablets under the brand name, Rybelsus.
Compounded Semaglutide is another GLP-1 receptor agonist similar to Ozempic and Wegovy. It is a cheaper alternative to these branded drugs and helps with weight loss by stimulating insulin secretion, supporting metabolic health, and reducing appetite.
People who prefer not to take injectable medications can consider using compounded oral Semaglutide. Oral Semaglutide is taken in pill form. It offers a convenient option for those who are not comfortable with injections or looking for cost-effective alternatives to Rybelsus.
Dosage and Administration
Semaglutide injections are administered through weekly subcutaneous injections while the oral forms are typically taken once a day. The treatment usually starts at a lower dose, followed by gradual increments in dosages, to optimize weight loss benefits and minimize side effects.
What is Mounjaro?
Mounjaro is a prescription medication that belongs to the class of drugs known as dual GLP-1 (glucagon-like peptide-1) and GIP (gastric inhibitory peptide) receptor agonists. The primary ingredient of this drug is Tirzepatide. [3]
The active ingredients of Mounjaro, Tirzepatide, work by mimicking the natural hormones GLP-1 and GIP. This mechanism of action is based on its ability to activate the GLP-1 and GIP receptors in the brain, which regulate hunger and fullness. [4]
By acting as a dual GLP-1 and GIP agonist, Tirzepatide slows gastric emptying, increases the feeling of fullness in the stomach, and reduces appetite. These effects contribute to faster weight loss.
In addition, its GIP receptor agonist effect further helps with weight loss by promoting fat metabolism.
These effects make Mounjaro particularly effective for weight loss. It helps control hunger pangs, reduces the temptation to overeat, and maintains stable blood sugar levels, which can prevent energy crashes that often lead to unhealthy snacking.
Mounjaro, by combining both GLP-1 and GIP agonism, provides a more dynamic approach to weight management. Research indicates that people using Mounjaro can acheive significant reductions in their body weight, often achieving greater results than those using Semaglutide alone.
Compounded Tirzepatide offers a cheaper alternative to Mounjaro. It contains the same active ingredient, Tirzepatide.
Compounded Tirzepatide offers a tailored approach to weight management and helps with weight loss by reducing hunger cravings and increasing feelings of fullness.
Dosage and Administration
Mounjaro is administered via a subcutaneous injection, usually once per week. The exact dosage can be determined based on your body weight and specific health needs.
Mounjaro weight loss injections are given in the stomach, thigh, or upper arm, and it’s relatively simple to self-administer at home.
It’s important to follow your doctor’s instructions carefully and monitor your progress. You can talk to our healthcare experts at Amp Health to find out the most suitable medication dosage, depending on your current weight, weight loss goals, and personal preferences.
How Semaglutide Works for Weight Loss
Semaglutide weight loss works primarily by targeting multiple pathways in the body to support weight loss and overall metabolic health, as explained below.
Reducing Appetite
Semaglutide weight loss injections influence the brain’s hunger signals, specifically by mimicking the action of a hormone called glucagon-like peptide-1 receptors.
This hormone is naturally released after meals to signal fullness and reduce the desire to eat.
Semaglutide, by activating GLP-1 receptors in the brain, helps curb excessive hunger, making it easier for you to control your food intake and avoid overeating.
Slowing Gastric Emptying
One of the significant mechanisms of Semaglutide is its ability to slow the rate at which food leaves the stomach. This not only enhances feelings of satiety (a feeling of fullness) but also helps regulate blood glucose levels by slowing the digestion and absorption of carbohydrates.
As a result, you may experience prolonged periods of feeling full, which can contribute to reduced overall calorie intake.
Enhancing Insulin Sensitivity
Semaglutide was initially approved for the treatment of type 2 diabetes. It helps improve insulin sensitivity, meaning the body becomes more effective at using insulin to regulate blood sugar levels in patients with type 2 diabetes.
This helps manage blood glucose levels more effectively, reducing fluctuations that can lead to cravings, hunger spikes, and impulsive eating. Better blood sugar management also supports stable energy levels and healthier metabolism, both of which are beneficial for weight management.
Together, these mechanisms create a comprehensive approach to weight loss and metabolic health, making Semaglutide a popular choice for individuals looking to manage their weight and improve their overall well-being.
How Mounjaro Works for Weight Loss
Mounjaro, a brand medication containing Tirzepatide, manufactured by Eli Lilly, offers several benefits, making it an appealing option for weight loss:
Effective Appetite Control
Mounjaro reduces food cravings and makes it easier for you to lower your calorie intake and lose stubborn fat. [5]
Improved Blood Sugar Control
Mounjaro helps regulate blood sugar levels. This can help you maintain energy boosts. This can lower the chances of binge eating after a period of fasting or low-calorie intake, thus contributing to weight loss. [6]
Long-Term Weight Management
Studies have shown that Mounjaro can promote sustained weight loss when combined with lifestyle changes. [7]
Reduced Risk of Weight-Related Health Conditions
By supporting chronic weight management, Mounjaro can also lower the risk of developing conditions like heart disease, high blood pressure, and sleep apnea. It can also improve cardiovascular health, lower cholesterol levels, and decrease the risk of heart attacks and weight gain. [8]
Semaglutide vs. Mounjaro Comparison: Weight Loss Effectiveness
In clinical trials, Semaglutide weight loss injections have shown to produce substantial weight loss. The STEP program demonstrated that participants lost an average of 15% of their body weight with Semaglutide over 68 weeks. [9]
Mounjaro, with its dual-action approach, can produce similar or slightly higher results, with some participants losing up to 20% of their body weight. In the SURMOUNT-1 trial, participants treated with Mounjaro achieved an average weight loss of approximately 22.5% of their body weight over 72 weeks, which is higher than the weight loss seen with Semaglutide. [10]
This suggests that the Mounjaro weight loss results might have a slightly greater magnitude compared to Semaglutide.
The higher effectiveness of Mounjaro could be attributed to its dual-action mechanism. Semaglutide, on the other hand, has a longer track record and established efficacy in weight management, making it a well-documented option.
So, the choice between Semaglutide vs. Mounjaro for weight loss should be guided by your health goals and treatment preferences following discussions with your healthcare provider.
Semaglutide vs. Mounjaro: Which One Is Right for You?
Choosing the best weight loss medication between Semaglutide and Mounjaro depends on various factors, including:
Personal Health Conditions: Mounjaro may be preferable for those with higher blood sugar levels or insulin resistance, as its dual-action mechanism may provide better glycemic control.
Side Effects: Some people report milder adverse events with Mounjaro compared to Semaglutide weight loss injections. However, both may cause nausea, dizziness, or gastrointestinal discomfort initially.
Medical History and Budget: Budget considerations can influence the choice, as Mounjaro may be more expensive due to its combination approach. However, you can also consider compounded versions of Semaglutide or Mounjaro if you are looking for cheaper alternatives to branded drugs.
Consultation with Healthcare Providers: It is essential to discuss these options with a healthcare provider to determine the most suitable medication based on individual health needs and goals.
Here’s a quick summary of Semaglutide vs. Mounjaro to help you make informed decisions.
| Medication | Semaglutide | Mounjaro |
|---|---|---|
| Type | Generic medication | Brand medication containing generic compound, Tirzepatide |
| Indications | Prescribed for adults with obesity (BMI ≥30) or those who are overweight (BMI ≥27) | Prescribed when the patient’s weight loss target is more aggressive |
| Mechanism of Action | Single: GLP-1 Receptor Agonist | Dual: GLP-1 & GIP Receptor Agonist |
| Efficacy for Weight Loss | Effective for weight loss, but lower compared to Mounjaro | More effective for weight loss compared to Semaglutide |
| Metabolic Goals | Reductions in blood glucose levels and insulin resistance with Semaglutide are lower than those with Mounjaro. | More significant reductions in blood glucose levels and insulin resistance than Semaglutide. |
| Dosage Form | Injectable and oral | Injectable |
| Frequency | Weekly for injectable and daily for oral | Weekly |
| Side Effects | Nausea, Vomiting, Diarrhea, Constipation, Fatigue | Nausea, Vomiting, Diarrhea, Constipation, Fatigue |
| Cost | $900 to $1,500 per month | $1,000 to $1,800 per month |
Semaglutide vs. Mounjaro: FAQs
Do you lose more weight on Mounjaro or Semaglutide?
Mounjaro and Semaglutide both offer effective weight loss benefits, but Mounjaro tends to provide slightly higher weight loss results due to its dual-action mechanism. Mounjaro targets both GLP-1 and GIP receptors, which helps enhance appetite suppression and insulin sensitivity, resulting in more significant weight loss outcomes.
So, while both medications are effective, the wider effects of Mounjaro may yield slightly better results for those looking for substantial weight loss.
Can I lose 20 pounds in a month with Semaglutide?
Yes, weight loss of 20 pounds per month is possible but uncommon and also unlikely to be sustained. Individual results vary significantly depending on factors such as diet, exercise routines, and medication dosage.
Does Mounjaro have fewer side effects than Ozempic?
The dual-action approach of Mounjaro may cause fewer gastrointestinal side effects compared to Ozempic, though individual experiences can vary.
What is better than Mounjaro for weight loss?
Compounded Tirzepatide and compounded versions of GLP-1 medications for weight loss, such as oral and injectable Semaglutide, may offer better solutions for weight loss, especially if you are looking for cheaper alternatives to branded weight loss drugs.
Conclusion
Semaglutide vs. Mounjaro comparisons show that both these drugs are effective for weight management, each offering unique benefits depending on individual health needs.
Semaglutide focuses on appetite suppression and insulin sensitivity and Mounjaro provides a more comprehensive approach by addressing hunger, fat burning, and glycemic control. Ultimately, consulting a healthcare provider will help you determine which option aligns best with your personal goals and medical history.
If you are considering weight loss medications for supporting your journey toward better health and fitness, book an appointment with our experts at Amp Health to learn more about Semaglutide vs. Mounjaro comparison.
You can subscribe to our Amp Health Program, which includes consultations with our doctor, nutritionist, and coach, in addition to the monthly subscription of compounded Semaglutide ($79/month + cost of medication).
If you have any medical questions or concerns, please talk to your healthcare provider. The articles on our website are based on information drawn from medical research, societies and governmental agencies. However, they are not a substitute for professional medical advice, diagnosis, or treatment.
DISCLAIMER
If you have any medical questions or concerns, please talk to your healthcare provider. The articles on our website are based on information drawn from medical research, societies and governmental agencies. However, they are not a substitute for professional medical advice, diagnosis, or treatment.
References:
- https://pubmed.ncbi.nlm.nih.gov/36188627/
- https://pubmed.ncbi.nlm.nih.gov/36121652/
- https://pubmed.ncbi.nlm.nih.gov/36751934/
- https://www.ncbi.nlm.nih.gov/books/NBK585056/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10159347/
- https://pubmed.ncbi.nlm.nih.gov/38388874/
- https://www.ncbi.nlm.nih.gov/books/NBK585056/
- https://pubmed.ncbi.nlm.nih.gov/37932236/
- https://pubmed.ncbi.nlm.nih.gov/33567185/
- https://www.nejm.org/doi/full/10.1056/NEJMoa2206038
