Oral Semaglutide has emerged as a promising option for weight loss, especially for those who prefer an alternative to injections.
This medication has gained attention for its effectiveness in promoting weight reduction.
In this blog, we’ll explore the proper use of oral Semaglutide for weight loss, including dosage guidelines, tips for maximizing its benefits, and considerations to keep in mind for a safe and successful experience.
What is Oral Semaglutide?
Oral Semaglutide is a medication used for weight management. It belongs to a class of drugs known as GLP-1 receptor agonists, which support weight loss by lowering appetite and delaying gastric emptying.
Oral Semaglutide is marketed under the brand name Rybelsus and is often prescribed as part of a comprehensive treatment plan that includes diet and exercise. [1]
Compounded oral Semaglutide tablets and drops offer alternatives to Rybelsus, the commercially available form of oral Semaglutide. Compounded Semaglutide is typically available at a lower price, offering a cost-effective solution to branded oral weight loss medications like Rybelsus.
What Are the Available Forms Of Oral Semaglutide?
Some available forms of oral Semaglutide include:
Rybelsus Tablets: This is the commercially available form of oral Semaglutide used for weight loss. Rybelsus tablets are taken once daily and are available in standard dosages of 3 mg, 7 mg, and 14 mg.
Compounded Oral Semaglutide Tablets: These are customized versions of Semaglutide tablets created by compounding pharmacies. They can be tailored to specific dosages that might not be available in the commercial form, offering personalized treatment options.
Compounded Oral Semaglutide Drops: This is a liquid form of oral Semaglutide. The drops can be easier to administer for those who have difficulty swallowing tablets and allow for more flexible dosing adjustments.
These oral forms offer people different ways to incorporate Semaglutide into their weight loss plan, depending on their specific needs and preferences.
For example, Semaglutide tablets are beneficial for people who travel frequently and need a portable solution. Compounded Semaglutide drops are suitable for those who prefer liquids over injections and tablets. These drops are administered sublingually. This means they are placed under the tongue. The sublingual delivery of Semaglutide drops can facilitate quicker absorption of the medication.
If you are looking for a customized or cheaper version of Semaglutide, you can make a telehealth appointment with our weight loss experts. Our doctors will analyze your case and prescribe the most suitable strength and form of compounded Semaglutide. This will help you achieve your weight loss goals without having to invest heavily in your treatment.
What Is Oral Semaglutide Used For?
Oral Semaglutide is used to support weight loss. Clinical trials have shown that higher doses of oral Semaglutide can lead to significant weight loss, similar to that achieved with its injectable counterparts, Ozempic and Wegovy. [2] [3]
The safety, effectiveness, and tolerability of oral Semaglutide is similar to the subcutaneous injectable versions of Semaglutide.
How Does Oral Semaglutide Work?
Oral Semaglutide works by mimicking the action of GLP-1 (glucagon-like peptide-1), which plays a role in controlling appetite. It acts on the GLP-1 receptors and regulates the appetite centers in the brain, inducing a sensation of fullness in the stomach.
Furthermore, Semaglutide delays gastric emptying, leading to a prolonged feeling of satiety. [4] This helps reduce appetite, leading to lower calorie consumption and, ultimately, weight loss.
How Is Oral Semaglutide Supplied?
Rybelsus, a popular brand of oral Semaglutide, is supplied as tablets available in three standard dosages: 3 mg, 7 mg, and 14 mg.
Compounded oral Semaglutide tablets are customized by compounding pharmacies. They can be supplied in a variety of dosages based on the specific needs of the patient.
Oral Semaglutide drops are supplied in liquid form. The concentration and volume of the drops are tailored to the patient’s specific dosage requirements, providing an easy-to-administer alternative for those who prefer or require a liquid form.
Each form of oral Semaglutide offers different options for administration and dosing, making it easier for patients and healthcare providers to choose the best fit for their weight loss plan.
How To Use Oral Semaglutide: Dosing Schedule
Oral Semaglutide is typically taken once daily.[2]
The initial dose of Rybelsus is usually 3 mg taken once daily for the first 30 days. This low dose helps your body adjust to the medication and minimizes potential side effects, such as nausea. After 30 days, the dose is typically increased to 7 mg once daily. This is the standard maintenance dose for most patients.
If weight loss is deemed to be slow, the dose may be increased to 14 mg once daily after taking the 7 mg dose for at least 30 days.
Rybelsus should be taken on an empty stomach, at least 30 minutes before your first meal of the day. It should be swallowed whole with plain water. After taking Rybelsus, you should wait at least 30 minutes before eating, drinking, or taking any other oral medication.
Compounded Semaglutide, unlike commercially available Rybelsus tablets, can be prescribed in specific strengths that match your exact dosage requirements. Whether you need a lower or higher dose than what’s available in Rybelsus, specialized compounding pharmacies can create tablets in precise amounts tailored to your needs.
If your dosage needs change over time, compounded tablets can be easily adjusted. This flexibility allows your healthcare provider to fine-tune your treatment without the limitations of standard doses.
Weight Loss With Oral Semaglutide Vs. Injectable Semaglutide
Both oral and injectable forms of Semaglutide have demonstrated significant weight loss in clinical studies, but there are some differences in their effectiveness.
Clinical trials for Wegovy, the injectable form, have shown substantial weight loss, with participants losing an average of 15% of their body weight over a year.
Oral Semaglutide has also been effective for weight loss, though generally, it is slightly less effective compared to its injectable counterpart. Trials have reported an average weight loss of about 5% to 15% of body weight. [7]
What Are the Most Common Side Effects of Oral Semaglutide?
Some common side effects of Semaglutide include:
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Gastroparesis
- Pancreatitis
Who Should Not Use Oral Semaglutide?
Oral Semaglutide may not be suitable for everyone. It is generally advised to avoid this medication if you:
- Have a history of Medullary Thyroid Carcinoma or Multiple Endocrine Neoplasia Syndrome Type 2
- Have a known allergy to Semaglutide
- Have severe gastrointestinal conditions
- Are pregnant or breastfeeding
What Should I Know About Oral Semaglutide Before Using It?
Here’s what you should know about oral Semaglutide before using it:
- You’ll need to take oral Semaglutide first thing in the morning, at least 30 minutes before your first meal of the day. [8]
- Swallow the tablet with a small amount of plain water.
- Make sure to swallow the tablet whole. Don’t crush, chew, or break it, as this can affect how the medication works.
- For the best results, take the medication consistently at the same time each day. This will help maintain its effectiveness.
- Be aware of potential side effects, such as nausea, vomiting, or stomach pain. These are common but usually decrease over time as your body gets used to the medication.
- Your dosage will start low and increase gradually to help your body adjust and reduce the risk of side effects.
- Before starting, talk to your doctor about your medical history, especially if you have any kidney, liver, or stomach issues, as these can affect how you use Semaglutide.
- Regular check-ins with your healthcare provider are important to monitor your progress and adjust your dosage if needed.
At Amp Health, our weight loss experts will monitor your weight loss progress and modify dosages depending on the results. Our doctors will also recommend dietary and lifestyle strategies to improve weight loss.
What Should I Tell My Healthcare Provider Before Using Oral Semaglutide?
Before starting oral Semaglutide, provide your healthcare provider with comprehensive information about your medical history and allergies to ensure safe and effective treatment. You must also inform your provider if you are breastfeeding, pregnant, planning to become pregnant, or suspect you might be.
Does Oral Semaglutide Interact with Foods Or Drinks?
Oral Semaglutide, like many medications, may be affected by certain foods and drinks, which might influence its effectiveness or increase the risk of side effects.
For example, heavy meals may delay the absorption of oral Semaglutide, potentially reducing its effectiveness. Hence, it’s generally advised to take the medication on an empty stomach to maximize absorption. For optimal results, take oral Semaglutide about 30 minutes before your first food or drink of the day. This timing helps ensure the medication is absorbed properly.
Some dietary modifications to maintain the effectiveness include limiting foods high in fat, eating slowly, reducing portion sizes, stopping when experiencing fullness, and not eating late at night. [9] [10]
Does Oral Semaglutide Interact with Other Medicines?
Oral Semaglutide can interact with some medications, which can interfere with its efficacy or change its side effect profile.
Here’s a list of some drugs that may interact with Semaglutide:
- Adderall (amphetamine / dextroamphetamine)
- Claritin (loratadine)
- Crestor (rosuvastatin)
- Eliquis (apixaban)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Lexapro (escitalopram)
- Lyrica (pregabalin)
- Wellbutrin (bupropion)
- Zoloft (sertraline)
How Should I Store Oral Semaglutide?
Rybelsus tablets should be stored at room temperature. Avoid exposing it to extreme temperatures. Store the medication in a dry place, away from moisture.
Do not store it in the bathroom or any other humid environment.
The storage instructions for compounded Semaglutide drops and tablets vary depending on the specific formulation of the pharmacy. Your healthcare expert at Amp Health will inform you the right way to store your medication to prevent spoilage and maintain its efficacy.
In addition, you should store your medication out of reach of children and pets to avoid accidental ingestion. Regularly check the expiration date on the medication container. Do not use it past its expiration date. Discard any expired medication properly.
What Should I Do If I Accidentally Use Too Much Oral Semaglutide?
If you accidentally take more oral Semaglutide than prescribed, reach out to your healthcare provider as soon as possible. They can provide specific instructions based on your situation.
In addition, pay attention to any unusual symptoms or side effects and make a note of the amount taken and the time of the overdose. This information can be useful for healthcare professionals.
If you experience severe symptoms or an adverse reaction, seek medical attention immediately. Call emergency services or go to the nearest emergency room.
Most importantly, ensure you understand the correct dosage and administration instructions to avoid future mistakes.
What Should I Do If I Miss A Dose Of Oral Semaglutide?
If you realize the missed dose, skip it and continue with your regular dosing schedule at the next scheduled time.
If you frequently miss doses, consider setting alarms or using medication reminders to help ensure you take your medication as prescribed. [11]
How to Use Oral Semaglutide: Frequently Asked Questions
How Long Does It Take for Oral Semaglutide to Start Working?
Oral Semaglutide typically begins to show weight loss effects within a few weeks of starting treatment.
Some people notice a reduction in weight as early as 4 weeks after beginning oral Semaglutide. More noticeable and sustained weight loss generally occurs between 8 to 12 weeks of treatment.
What Should Be Done Before Starting Oral Semaglutide Therapy?
Before starting oral Semaglutide therapy, schedule a thorough consultation with our weight loss experts at Amp Helah to discuss your medical history, current health status, and any underlying conditions. This will help your doctor determine if oral Semaglutide is appropriate for you.
You can also discuss how oral Semaglutide fits into your overall weight management plan, including dietary changes and physical activity.
Is Rybelsus the Same as Ozempic, Wegovy, and Saxenda?
Rybelsus, Ozempic, Wegovy, and Saxenda are all medications that contain the active ingredient, Semaglutide, or similar GLP-1 agonists, but they come in different formulations.
Oral Semaglutide Testimonials
“Amp Health provided clear guidance on the proper use of Oral Semaglutide, making it easy to incorporate it into my routine. Their support ensured I used the medication correctly and maximized its benefits. Excellent service and straightforward instructions!”
– 25/Male
“I appreciate how Amp Health explained the proper use of Oral Semaglutide in detail. Their thorough instructions and follow-up support have been invaluable in my weight loss journey. The medication is working as expected.”
– 29/Female
“The team at Amp Health made using Oral Semaglutide simple and effective. Their detailed guidance on dosage and usage helped me get the best results. I’m pleased with the clarity and support provided throughout the process.”
– 39/Male
Conclusion
Using Semaglutide correctly is essential for achieving the best weight loss results. Following your healthcare provider’s instructions, including the right dosage, timing, and administration method, ensures the medication works effectively and safely.
Whether you’re using oral Semaglutide brands like Rybelsus or the compounded version of the medication, consistency and proper usage are key to maximizing benefits and minimizing side effects.
You can talk to our healthcare experts to learn more about the right way to use oral Semaglutide to lose weight effectively. You can subscribe to our Amp Health Program, which includes consultations with our doctor, nutritionist, and coach, in addition to the monthly subscription of compounded Semaglutide ($79/month + cost of medication).
DISCLAIMER
If you have any medical questions or concerns, please talk to your healthcare provider. The articles on our website are based on information drawn from medical research, societies and governmental agencies. However, they are not a substitute for professional medical advice, diagnosis, or treatment.
References:
- https://pubmed.ncbi.nlm.nih.gov/36208922/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969659/
- https://pubmed.ncbi.nlm.nih.gov/31186120/
- https://www.ncbi.nlm.nih.gov/books/NBK551568/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815186/
- https://pubmed.ncbi.nlm.nih.gov/37385278/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815186/pdf/IJEM-26-417.pdf
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969659/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807016/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8736331/
- https://www.rybelsus.com/content/dam/diabetes-patient/rybelsus/english/rybelsus-brochure-1121.pdf